Aquaporin 4 autoantibody with complement may be pathogenic in neuromyelitis optica

Takeaway

  • Repeated intrathecal injections of aquaporin 4 (AQP4) autoantibody with complement in experimental autoimmune encephalomyelitis (EAE) mice resulted in pathologic changes similar to human neuromyelitis optica (NMO).

Why this matters

  • AQP4 antibody (NMO-IgG) is considered a disease-specific marker of NMO pathology, but it is unclear whether the antibody itself is pathogenic.