Are C-reactive protein levels associated with cognitive function and Alzheimer’s disease biomarker expression?


  • Higher baseline C-reactive protein (CRP) levels were associated with reduced cognitive function and in vivo biomarkers of Alzheimer’s disease (AD).

Why this matters

  • People who carry the apolipoprotein E (APOE) ε4 allele are at high risk of developing AD, but not all APOE ε4 carriers develop dementia, suggesting that other factors may contribute.

  • The involvement of CRP in modulating AD risk in APOE ε4 carriers may suggest benefit of chronic low-grade anti-inflammatory treatment in these individuals to delay AD onset.