Low-density lipoprotein receptor related protein 4 (LRP4)/agrin autoantibodies from a patient with myasthenia gravis (MG) were pathogenic in mice.
Why this matters
The acetylcholine receptor (AchR) is the most common target of autoantibodies in MG, accounting for MG cases.
The agrin/LRP4/muscle-specific kinase (MuSK) pathway is key to neuromuscular junction (NMJ) formation and maintenance. Whether these proteins are pathogenic in MG has not previously been investigated.