Are low-density lipoprotein receptor related protein 4/agrin autoantibodies involved in myasthenia gravis pathogenesis?

Takeaway

  • Low-density lipoprotein receptor related protein 4 (LRP4)/agrin autoantibodies from a patient with myasthenia gravis (MG) were pathogenic in mice.

Why this matters

  • The acetylcholine receptor (AchR) is the most common target of autoantibodies in MG, accounting for MG cases.

  • The agrin/LRP4/muscle-specific kinase (MuSK) pathway is key to neuromuscular junction (NMJ) formation and maintenance. Whether these proteins are pathogenic in MG has not previously been investigated.