Assessing both infarcted and salvageable tissues to select patients for mechanical thrombectomy


  • Integrating functional measures from infarcted and salvageable brain tissue can help to predict treatment benefit from mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) and large ischemic core (LIC).

Why this matters

  • Patients with AIS-large vessel occlusion (LVO) and poor imaging profile at baseline were excluded from most trials of mechanical thrombectomy (MT).

  • A poor or unfavorable imaging profile is typically defined as a lesion with LIC and is a common reason to forego MT in clinical practice.

  • It remains unclear which patients with LIC may still gain benefit from MT; approaches to identifying which patients have the best outcomes with MT despite LIC are warranted.