Assessing prognostic outcome in young children with molecular subgroup-specific medulloblastoma


  • Young children with sonic hedgehog (SHH) medulloblastoma have significantly better survival outcomes compared with young children with Group 3/Group 4 medulloblastoma.

Why this matters

  • An understanding of which molecular subgroups of medulloblastoma respond well to irradiation-avoiding strategies can help to avoid unnecessary use of radiation-based treatment.

  • Clinicians can also use this information to escalate treatment when irradiation-avoiding strategies are less likely to improve prognostic outcome.