Takeaway
Lower 11C-Pittsburgh compound B (PiB) uptake is associated with Lewy body disease (LBD) without Alzheimer’s disease (AD) pathology, and the severity of amyloid-beta (Aβ) pathology is the primary reason for elevated PiB uptake.
Why this matters
Aβ pathology is common in people with AD, LBD, and dementia with Lewy bodies (DLB), and PiB is the most studied positron emission tomography (PET) ligand for Aβ.
Understanding Aβ PET findings in LBD and DLB is necessary to effectively use the biomarker of AD pathology in patients with probable DLB.