Association between blood pressure variability, cognitive decline and neuropathological changes in Alzheimer’s disease


  • Higher blood pressure (BP) variability may be associated with cognitive decline and early risk of dementia.

Why this matters

  • Hypertension is proposed to be a major contributor to risk of dementia, but the relationship between the two conditions remains to be fully elucidated.

  • Evidence to date suggests that excessive visit-to-visit BP variability may contribute to the risk of dementia, but it is yet to be shown whether this risk factor is relevant in early or advanced stages of dementia, or both.