Association between genetic risk for MS and brain development


  • Multiple sclerosis (MS) risk variants act upon the brain during preadolescent neurodevelopment.

Why this matters

  • Approximately 233 genetic variants have been identified that each contribute a small amount to the overall risk of developing MS.

  • Patients with MS tend to display smaller regional brain volumes and alterations in white matter microstructure when compared to individuals without MS.

  • Whether a genetic risk for MS is associated with developing such structural brain changes is yet to be determined.

  • A relatively limited window of opportunity for treatment of MS exists during childhood neurodevelopment, identifying those at risk could aid in facilitating prevention.