Association between interseizure interval and subsequent seizure duration in focal epilepsy


  • In refractory focal epilepsy, a longer interseizure interval (ISI) is associated with an increased probability of longer seizures, supporting the existence of a ‘capacitative effect’.

Why this matters

    Neurostimulation devices, such as a responsive neurostimulation device (RNS System) could estimate the timing and severity of upcoming seizures, optimizing clinical response by providing time-varying and risk-stratified therapy personalized to intrinsic memory processes.