Association between intracranial venous congestion and spaceflight-associated neuro-ocular syndrome


  • Astronauts with spaceflight-associated neuro-ocular syndrome (SANS) demonstrated significantly greater increases in pre-flight to post-flight intracranial dural venous volumes. 

Why this matters

  • Approximately 40% to 60% of astronauts who present with post-flight alterations in visual acuity, retinal injury, globe flattening, optic disk edema, and intracranial pressure (ICP) elevation experience SANS, but its etiology is largely unknown.

  • Results from this unique study suggest that abnormal venous flow may contribute to SANS, and astronauts with increased venous sinus congestion may be at increased risk of SANS development.