Association between long-term disability worsening and optical coherence tomography in MS


  • In people with multiple sclerosis (MS), below average ganglion cell+inner plexiform layer (GCIPL) thickness at baseline increased the odds of Expanded Disability Status Scale (EDSS) and visual acuity (VA) worsening at follow-up compared with people with average GCIPL thickness.

Why this matters

    MS is a central nervous system demyelinating disorder that commonly leads to optic neuropathy. Studies have suggested that time-domain optical coherence tomography (TD-OCT) may predict long-term disability, but the accuracy of modern spectral-domain OCT (SD-OCT) has not been evaluated past 5 years of follow-up in people with MS.