Association between multiple single-nucleotide variants for APOE and Alzheimer’s disease risk

Takeaway

  • Several single-nucleotide variants (SNVs) in the apolipoprotein E (APOE) region are associated with Alzheimer’s disease (AD) risk, including variants not found in the Ɛ2/Ɛ3/Ɛ4 alleles.

Why this matters

    The association between APOE and AD risk is well known, but it is not known whether this association is independent of the 2 missense variants, rs429358 and rs7412, located in the Ɛ2/Ɛ3/Ɛ4 alleles. Uncovering relationships between SNVs and AD risk will aid in identifying AD treatment targets.