Association between neuronal nitric oxide synthase and pain due to chronic pancreatitis


  • Neuronal nitric oxide synthase (nNOS) is specifically elevated in pancreatic nerves of people with chronic pancreatitis (CP) but not in those with pancreatic cancer (PCa) while inhibition of nNOS reduces pain in mouse models of CP.

Why this matters

  • Pancreatic pain suffered by people with CP is often severe, chronic and opiate resistant, nNOS inhibition as a therapeutic option to reduce this pain has the potential to positively impact these people.