Association between TIMP-1 levels and mortality and disability risk in ischemic stroke


  • Higher tissue inhibitor metalloproteinase-1 (TIMP-1) levels in acute ischemic stroke (AIS) were independently associated with increased risk of major disability and death.

  • Joint occurrence of higher TIMP-1 and matrix metalloproteinase-9 (MMP-9) was associated with higher risk of adverse outcomes.

Why this matters

    Extracellular matrix biomarkers may help predict clinical outcomes following AIS.