Association between white matter hyperintensities, repetitive head impacts, and neuropathy


  • White matter hyperintensities (WMH) may be associated with long-term white matter pathologies due to repetitive head impacts.

Why this matters

  • Repetitive head impacts from contact sports have been associated with an array of neuropathies, such as chronic traumatic encephalopathy (CTE) and white matter degeneration.

  • WMH on MRI has been associated with white matter neurodegeneration.

  • WMH may capture the effect of repetitive head impacts on white matter degeneration.