There was no evidence for human leukocyte antigen (HLA)-association in myelin oligodendrocyte glycoprotein-associated disease (MOGAD) in Dutch individuals of European ancestry, which suggests MOGAD and aquaporin 4-immunoglobulin G-positive (AQP4-IgG) neuromyelitis optica spectrum disorder (NMOSD) are distinct diseases of the central nervous system (CNS).
Why this matters
There is a potential role for HLA in the disease process for both MOGAD and AQP4-IgG NMOSD, two demyelinating syndromes of the CNS. To date, HLA associations in Dutch individuals of European ancestry have never been examined.
The results of this study will help clarify the pathophysiology of HLA in both diseases within this population.