Association of human leukocyte antigen in two demyelinating syndromes within a Dutch population


  • There was no evidence for human leukocyte antigen (HLA)-association in myelin oligodendrocyte glycoprotein-associated disease (MOGAD) in Dutch individuals of European ancestry, which suggests MOGAD and aquaporin 4-immunoglobulin G-positive (AQP4-IgG) neuromyelitis optica spectrum disorder (NMOSD) are distinct diseases of the central nervous system (CNS). 

Why this matters

  • There is a potential role for HLA in the disease process for both MOGAD and AQP4-IgG NMOSD, two demyelinating syndromes of the CNS. To date, HLA associations in Dutch individuals of European ancestry have never been examined.

  • The results of this study will help clarify the pathophysiology of HLA in both diseases within this population.