Association of memory scores with AD pathology markers in asymptomatic presenilin-1 E280A carriers

Takeaway

  • Free and Cued Selective Reminding Test (FCSRT) scores were associated with in vivo markers of AD pathology in cognitively unimpaired presenilin-1 E280A carriers genetically determined to develop dementia.

Why this matters

    Previous research has found that FCSRT is sensitive to memory decline in cognitively unimpaired adults with neurodegeneration. Detection of the earliest changes in cognitively unimpaired adults with a risk of developing dementia may be useful in clinical trials that aim to delay or prevent dementia onset in presymptomatic patients.