Association of mono-amine oxidase-A gene variants and glioblastoma development in men


  • The rs144551722 single nucleotide polymorphism (SNP) in the monoamine oxidase-A (MAO-A) gene was a significant predictor of development of glioblastoma in males but not in females.

Why this matters

    Preclinical studies suggest that the MAO-A enzyme may play a role in glioma development. The results from this study support investigations into MAO-A–inhibiting drugs as a potential treatment for glioma and MAO ‑A–genotype as a clinical marker.