A sharp decrease in lifetime physical activity (PA) was identified in patients with amyotrophic lateral sclerosis (ALS) prior to diagnosis.
Current and pre-diagnostic PA levels were associated with survival.
Why this matters
PA has previously been identified as a risk factor for ALS.
Case-control data from this Germany registry further consolidates PA as a disease-modifying factor in ALS and may lead to specific exercise recommendations in at-risk individuals.