Association of physical activity with amyotrophic lateral sclerosis onset and prognosis


  • A sharp decrease in lifetime physical activity (PA) was identified in patients with amyotrophic lateral sclerosis (ALS) prior to diagnosis.

  • Current and pre-diagnostic PA levels were associated with survival.

Why this matters

  • PA has previously been identified as a risk factor for ALS.

  • Case-control data from this Germany registry further consolidates PA as a disease-modifying factor in ALS and may lead to specific exercise recommendations in at-risk individuals.