Association of serum magnesium and calcium levels with ischemic stroke risk

Takeaway

  • Using Mendelian randomization (MR), an epidemiologic method that uses genetic variants as unbiased proxies for exposure, the study revealed decreasing cardioembolic stroke risk with increasing serum magnesium levels but no relationship between calcium and stroke risk.

Why this matters

  • Assessment using MR should provide a better indication of the causal effects of serum magnesium and calcium levels on stroke risk than limited available observational data.