Association of single nucleotide polymorphisms and Alzheimer’s disease

Takeaway

  • Single nucleotide polymorphisms (SNPs) have been identified that relate to cognitive decline, in a manner that cannot be explained by amyloid β (Aβ) or tau levels, providing insight into the complexity of the pathogenesis of Alzheimer’s disease (AD).

Why this matters ?

  • AD is a highly complex disease with multifactorial mechanisms. Understanding the pathomechanisms that are common as well as distinct from typical AD pathogenesis is important for the development of treatment strategies

  • The findings of this study support the growing literature on the role of glutathione in AD pathogenesis and may provide new treatment strategies for AD, such as anti-oxidative agents, for individuals with the identified SNPs.