Single nucleotide polymorphisms (SNPs) have been identified that relate to cognitive decline, in a manner that cannot be explained by amyloid β (Aβ) or tau levels, providing insight into the complexity of the pathogenesis of Alzheimer’s disease (AD).
Why this matters ?
AD is a highly complex disease with multifactorial mechanisms. Understanding the pathomechanisms that are common as well as distinct from typical AD pathogenesis is important for the development of treatment strategies
The findings of this study support the growing literature on the role of glutathione in AD pathogenesis and may provide new treatment strategies for AD, such as anti-oxidative agents, for individuals with the identified SNPs.