Association of white matter hyperintensities with Parkinson disease motor scores varies by lesion site


  • White matter hyperintensities (WMHs) in different anatomical locations have varying effects on Parkinson disease (PD) motor symptoms independently of dopaminergic degeneration; deep WMHs (DWMHs) were associated with bradykinesia, and periventricular hyperintensities (PVHs) were associated with bradykinesia and axial symptoms.

Why this matters

  • The severity of PD motor symptoms has been linked to WHMs in different anatomical locations, namely DWMHs and PVHs, but results are inconsistent across studies; none of the results have previously been adjusted for the severity of dopaminergic degeneration.

  • By adjusting for the degree of dopaminergic degeneration, this study allows the influence of WHMs on PD motor symptoms to be determined more accurately.