Associations between APOE e4 genotype and lifestyle risk factors for lower cognitive abilities

Takeaway

  • There were few associations between APOE e4 genotype and lifestyle-based risk factors for lower cognitive ability, suggesting a direct association between APOE e4 genotype and cognition.

Why this matters ?

  • The APOE e4 allele has previously been associated with lower cognitive abilities and the risk of dementia; but whether this is a direct association or mediated via increased vulnerability for lifestyle risk factors is poorly understood.