Conditioned pain modulation (CPM), offset analgesia (OA), spatial summation (SSP) and temporal summation of pain (TSP) assess different aspects of endogenous pain inhibition.
Why this matters
CPM, OA, SSP and TSP are commonly used paradigms for quantifying endogenous pain modulation. However, their underlying physiological mechanisms are not fully understood.
This study demonstrates that there is limited association between these four pain modulation paradigms, suggesting that they assess distinct aspects of endogenous analgesia with different underlying physiological mechanisms.