Associations between pain modulation paradigms


  • Conditioned pain modulation (CPM), offset analgesia (OA), spatial summation (SSP) and temporal summation of pain (TSP) assess different aspects of endogenous pain inhibition.

Why this matters

  • CPM, OA, SSP and TSP are commonly used paradigms for quantifying endogenous pain modulation. However, their underlying physiological mechanisms are not fully understood.

  • This study demonstrates that there is limited association between these four pain modulation paradigms, suggesting that they assess distinct aspects of endogenous analgesia with different underlying physiological mechanisms.