Associations between repetitive negative thinking and biomarkers for Alzheimer's disease


  • There is an association between repetitive negative thinking (RNT), cognitive decline, A𝛽 and tau burden in cognitively intact older adults.

Why this matters

    Depression and anxiety have been established as risk factors for cognitive decline and Alzheimer’s disease (AD). The Cognitive Debt Hypothesis suggests that a mechanism that frequently presents with these risk factors, namely RNT, may be the driving force behind this association. A better understanding of RNT will therefore help future researchers to better understand the causes of AD and ultimately develop disease modifying therapies for AD, of which there currently none.