Associations between small vessel cerebrovascular disease and neurodegeneration in older adults


  • White matter hyperintensities (WMH) were significantly associated with cortical atrophy – particularly in non-Hispanic Black participants – in brain regions typically affected by Alzheimer’s disease. 

Why this matters

  • Dementia prevalence has been reported at higher rates in adults of Hispanic and non-Hispanic Black descent.

  • This study provides evidence that cerebrovascular disease may influence Alzheimer’s disease risk and progression, and underlines the need for further study into factors that may contribute to racial disparities observed in neurodegeneration.