Associations between widowhood status and Aβ-related cognitive decline


  • Widowhood status was associated with accelerated cognitive decline, with more rapid decline occurring in those with higher levels of brain amyloid-beta (Aβ).

Why this matters

    To reduce the incidence of Alzheimer’s disease (AD) dementia, it is essential to develop preventative treatments for older adults at high risk of cognitive decline. Recent evidence has shown that widowhood status is independently associated with memory decline and increased risk of dementia. Assessing the association between widowhood status, cognitive decline and brain Aβ levels may help to inform the design of new detection and prevention initiatives for unimpaired older adults using biomarker-based diagnostic tests for AD.