Asymptomatic optic nerve lesions may contribute to retinal nerve fiber layer (RNFL) atrophy resulting in higher visual disability in individuals with remitting-relapsing multiple sclerosis (RRMS).
Why this matters
Optic nerve lesions can cause optic neuritis (ON) in individuals with MS, which eventually leads to visual disability due to axonal degeneration and RNFL atrophy. Some individuals with MS are considered asymptomatic when they have optic nerve lesions without ON. The results of this study will help with understanding how frequent optic nerve lesions are in asymptomatic individuals with MS.