Atrophy and cognitive profiles in older adults with temporal lobe epilepsy


  • Overlap of medial temporal lobe atrophy (TLA) and cognitive impairment (CI) was seen between older adults with temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (MCI).

Why this matters ?

  • Pathological brain aging is a particular concern for patients with TLE; however, whether the shared cognitive dysfunction observed in these and patients with amnestic MCI corresponds to similar cortical and hippocampal atrophy patterns is unknown.

  • Overlaps in brain atrophy and CI in older adults with TLE and MCI highlights potential issues of accelerated aging and comorbid Alzheimer’s disease in these patients, suggesting an urgent need for research to identify common pathology, and to target shared symptoms.