Atrophy network mapping localizes clinical symptoms to brain networks in people with dementia

Takeaway

  • Brain atrophy in clinical dementia is observed in syndrome-specific functionally connected brain networks.

Why this matters

    The clinical and neuroanatomical heterogeneity in individuals with Alzheimer’s disease hinders the development of neuroimaging biomarkers to monitor disease progression and treatment response. These findings support the use of atrophy network mapping as a novel method to localize clinical symptoms to brain networks in people with dementia.