Attention-deficit hyperactivity disorder and Alzheimer’s disease: is there a shared familial risk?

Takeaway

  • Attention-deficit hyperactivity disorder (ADHD) was associated with Alzheimer’s disease (AD) and any dementia within families. The association strength was reduced as genetic relatedness decreased.

Why this matters

  • Several studies have suggested an association between ADHD and AD, but results have been conflicting.

  • This large population-based study underlines the importance of further research into ADHD pathophysiology and cognitive decline in older age, in order to unravel the potential shared genetic mechanisms between these two conditions.