Autonomic nervous system abnormalities may worsen during early multiple sclerosis


  • A considerable percentage of participants with clinically isolated syndrome (pwCIS) associated with multiple sclerosis (MS) experienced worsening of autonomic nervous system (ANS) abnormalities over a 2-year period, which could be predicted by magnetic resonance imaging (MRI) results.

Why this matters

  • While it is known that the ANS is frequently involved in CIS and MS, little research has been done to identify what happens to ANS functions throughout the MS disease course.

  • Understanding the progression or regression of ANS during the MS disease course, and how it can be predicted, will aid clinicians in providing patient-centered treatment that addresses multiple aspects of the disease.