Autosomal dominant genetic predictors of survival in frontotemporal degeneration


  • For people with behavioral variant frontotemporal degeneration (bvFTD), survival time and age at onset are independently predicted by autosomal dominant mutations in C9orf72, progranulin (GRN) or microtubule-associated protein tau (MAPT).

Why this matters

    Trajectories of disease progression related to autosomal dominant mutations may be useful in both informing clinical trial design and in counseling of patients and families in a clinical setting.