Axonal injury detection in individual patients following traumatic brain injury


  • Evidence of a proposed pipeline’s efficiency to diagnose traumatic brain injury (TBI) in individual patients at subacute and chronic timepoints, and of diffusion tensor imaging (DTI) as a sensitive and complementary tool for measures of diffuse vascular injury is provided.

Why this matters

  • Diffuse axonal injury (DAI) plays a key role in the pathophysiology of TBI, and is difficult to assess clinically – current assessment includes clinical presentation, visible white matter damage or surrogate markers including microbleeds; which do not accurately quantify DAI and can lead to misdiagnosis in some patients.

  • Implementation of a sensitive diagnostic pipeline for individual cases of TBI may potentially improve diagnostic accuracy and outcome predictions, leading to more effective and appropriate care, and optimal outcomes for patients.