Bidirectional propagation of Parkinson’s disease pathology in non-human primates

Takeaway

  • In a non-human primate model, human α-synuclein Parkinson’s disease (PD) pathology propagated bidirectionally between the central and enteric nervous systems.

Why this matters

    This report of the involvement of the gut-brain axis in the initiation and propagation of PD pathology reveals a new potential pathway for development of PD therapeutics.