Bilateral structural network abnormalities relate to seizure activity in bottom-of-sulcus dysplasia-associated epilepsy


  • Epilepsy associated with bottom-of-sulcus dysplasia (BOSD) is likely characterized by disruptions in a common bilateral structural network, and these abnormalities may partly relate to seizure activity.

Why this matters

  • Focal cortical dysplasia (FCD) has been recently recognized as a network disorder, but the heterogeneity of epileptogenic lesions hinders the probing for network-wide specific structural disruptions.

  • BOSD is an FCD with distinctive neuropathological and neuroimaging hallmarks. It remains unclear whether BOSD is characterized by disruption to specific brain networks, and the structural networks that are affected.

  • This study supports early seizure control through surgery to inhibit the progression of fiber tract disruptions that may relate to chronic epilepsy in patients with BOSD.