Biomarker assessments help to differentiate between Alzheimer’s disease and depressive disorder

Takeaway

  • In addition to clinical symptoms and behavioral testing, biomarker assessment is also needed to differentiate between Alzheimer’s disease and depressive disorder.

Why this matters

    Symptoms of Alzheimer’s disease and depressive disorder can overlap with both being linked to depressed mood and cognitive impairment, hindering the differential diagnosis of each condition based on clinical and behavioral grounds alone. This is the first study to use biomarker verified groups of each condition to characterize their cognitive profiles and confirm that free delayed recall is not reliable enough for differential diagnosis.