Biomarker predicts future dementia in isolated rapid eye movement sleep behavior disorder

Takeaway

  • The deformation score of the brain-clinical signature, associated with iRBD, indicates increased likelihood of developing a synucleinopathy in the future.

Why this matters

    The pattern of brain-clinical features of iRBD may be used as a biomarker to predict the likelihood of developing cognitive impairment and could aid in targeted therapies.