Biomarkers for Amyotrophic Lateral Sclerosis

Takeaway

  • This study suggests that total tau (tTau) levels in the cerebrospinal fluid (CSF) and the phosphorylated tau/total tau (pTau/tTau) ratio can serve as diagnostic biomarkers for amyotrophic lateral sclerosis (ALS).

Why this matters ?

    tTau and pTau have been proposed as potential biomarkers for other neurodegenerative disorders; however, the clinical usefulness of tTau and pTau as diagnostic biomarkers in ALS is still debated.