Biomarkers of cerebral small vessel disease and dementia predict onset of mild cognitive impairment

Takeaway

  • White matter hyperintensities burden is linked to time of onset of mild cognitive impairment in people with low levels of cerebrospinal fluid t-tau.

Why this matters

    These findings suggest that small vessel cerebrovascular disease, as indicated by white matter hyperintensities, increases the risk of progression to mild cognitive impairment when levels of neurodegeneration are low.