Body composition of people with myotonic dystrophy types 1 and 2

Takeaway

  • Percentage fat mass (FM) and decreased bone mineral density (BMD) were associated with muscle weakness in people with myotonic dystrophy type 1 (DM1) and type 2 (DM2), respectively.

Why this matters

  • In people with DM1 and DM2, obesity and osteoporosis therapeutic interventions should be considered to delay further muscle weakness.

  • Body composition parameters could be used as biomarkers to assess efficacy of gene therapy in clinical trials.