Brain abnormalities in people with neuromyelitis optica spectrum disorders

Takeaway

  • Non-specific white matter changes are the most frequent brain abnormality observed via magnetic resonance imaging (MRI) in people with neuromyelitis optica spectrum disorders (NMOSD), and cognitive impairment appears to be independent of lesion development.

Why this matters

  • Brain MRI abnormalities in NMOSD have been reported, but lesions have not been fully characterized and associations between MRI characteristics and clinical outcomes are unknown.

  • Presence and type of brain abnormalities on MRI does not appear to be a useful marker for predicting cognitive impairment in people with NMOSD.