Brain-age predictions using magnetic resonance imaging in patients with multiple sclerosis


  • Brain-predicted age difference (brain-PAD) is sensitive to neurological changes associated with multiple sclerosis (MS), and may be useful in assessing prognosis and disease progression.

Why this matters

  • Age has a significant impact on the clinical course of MS and drives disease progression.

  • Longitudinal neuroanatomical data from magnetic resonance imaging (MRI) scans can be used to predict the chronological age of a subject, known as their “brain-age”.

  • Brain-predicted age difference (brain-PAD) is a measure of a persons’ brain-age prediction compared to their chronological age, and may be sensitive to brain changes associated with MS.