Brain cholesterol metabolism in Huntington’s disease

Takeaway

  • Expression of the neuronal enzyme cholesterol 24-hydroxilase (CYP46A1), part of the major cholesterol catabolism pathway in the brain, improved behavioral and neuropathological phenotypes in a mouse model of Huntington’s disease.

Why this matters

    Maintaining or restoring cholesterol homeostasis may be protective against neurodegenerative diseases.