Brain connectivity and cognitive impairment in Parkinson’s disease

Takeaway

  • Individuals with Parkinson’s disease (PD) and cognitive impairment (PD-CI) have decreased functional connectivity in several brain regions compared to both healthy controls and cognitively unimpaired individuals with PD (PD-CU).

Why this matters

    This study clarifies confusion in the pathophysiology associated with cognitive impairment in PD and highlights the default mode network as a potential biomarker for CI in PD.