Brain function in post-traumatic headache after mild traumatic brain injury


  • Hypothalamic functional connectivity (FC) is disrupted in patients with acute mild traumatic brain injury (mTBI) and resulting post-traumatic headache (PTH); furthermore, abnormal hypothalamic FC correlates with headache frequency and intensity.

Why this matters

  • Post-traumatic headache is a common sequela of mild traumatic brain injury; past research has implicated hypothalamic involvement in migraine and other pain disorders, but no studies have examined potential associations between the hypothalamus and PTH.

  • The correlation between abnormal hypothalamic FC and PTH features may have potential implications for treatment strategies and targeted therapy development; however further research is needed.