Brain glucose metabolism is altered in patients with idiopathic REM behavior disorder


  • Idiopathic rapid eye movement (REM) behavior disorder (iRBD) show several differences in
    [18F]-fluorodeoxyglucose positron emission tomography ([18F]FDG PET) uptake compared with Parkinson’s disease (PD), Lewy body dementia (DLB), Alzheimer’s disease (AD), and controls, with the main differences documented in the comparison with AD patients.

Why this matters

  • Neuronal energy glucose damage occurs in iRBD patients due to altered brain glucose metabolism; glucose damage may be the possible expression of the neurodegenerative processes already affecting these patients.