Brain-heart crosstalk and mortality in traumatic brain injury


  • A healthy brain-heart relationship may be a predictive factor for survival following traumatic brain injury (TBI).

Why this matters

  • TBI is a complex pathology that affects up to 60 million people worldwide every year and has been deemed a public health priority in Europe.

  • Effective management of TBI in critical care requires several physiological inputs, including data on intracranial pressure (ICP) and heart rate (HR).

  • There has been significant interest in the role of brain-heart crosstalk, however, the interaction and possible implications for outcomes have not been well-studied in TBI.

  • It is possible that measures of brain-heart crosstalk derived from ICP and HR data could be predictive factors in survival following TBI.