Brain network centrality alterations in middle-aged patients with retinitis pigmentosa

Takeaway

  • Middle-aged patients with retinitis pigmentosa (RP) demonstrate anomalous network activity in various brain regions, which may underlie pathologic mechanisms of RP.

Why this matters

  • Retinitis pigmentosa (group of heritable retinal degeneration diseases characterized by constricted visual fields, photoreceptor cell dysfunction, and apoptosis) progression may be linked to hemispheric synchronization and brain structural damage, but this remains unclear; however, utilizing voxel-wise degree centrality (DC) methods may provide some insight.

  • Voxel-wise DC may serve as a potentially useful clinical indicator to monitor RP based on its demonstration of abnormal network activity in patients with RP.