Brain network imbalance as a diagnostic biomarker in Rolandic epilepsy


  • Brain excitatory and inhibitory (E/I) imbalance is a potential biomarker for Rolandic epilepsy, and possibly involved in the pathogenesis of seizures and cognitive impairment.

Why this matters ?

  • Rolandic epilepsy is an idiopathic condition with onset in childhood, accounting for around 15.7% of epilepsy cases. Rolandic epilepsy has a variable prognosis that is very poor in some children, resulting in irreversible cognitive deficits.

  • The E/I imbalance theory describes how an imbalance in the excitatory versus inhibitory electrical activity in the brain can result in episodes of transient epileptiform activity, and ultimately seizure. However, the mechanism of how E/I imbalance may lead to epilepsy remain unknown.

  • Examining the relationship between E/I imbalance and Rolandic epilepsy in children is an ideal starting point for modelling neural activity to better understand the role of E/I imbalance in epileptogenesis.